Cystic fibrosis dating another cystic fibrosis patient

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Bonnie Bassler, Hibbins was part of a research effort which shed light on how the bacteria that cause cholera form biofilms and communicate via quorum sensing.“Forming a biofilm is one of the crucial steps in cholera’s progression,” states Bassler.

A variety of different molecules can be used as signals.

In an article titled “Bacterial Biofilms: A Common Cause of Persistent Infections,” JW Costerton at the Center for Biofilm Engineering in Montana defines a bacterial biofilm as “a structured community of bacterial cells enclosed in a self-produced polymeric matrix and adherent to an inert or living surface.” In layman’s terms, that means that bacteria can join together on essentially any surface and start to form a protective matrix around their group.

The matrix is made of polymers – substances composed of molecules with repeating structural units that are connected by chemical bonds.

If the colonists are not immediately separated from the surface, they can anchor themselves more permanently using cell adhesion molecules, proteins on their surfaces that bind other cells in a process called cell adhesion.

These bacterial pioneers facilitate the arrival of other pathogens by providing more diverse adhesion sites.

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